Description
SS-31 (also known as elamipretide or MTP-131) is a synthetic peptide that specifically targets the mitochondria—the cell’s energy producers. It works by protecting these powerhouses from damage, reducing oxidative stress, and boosting cellular energy production.
How It Works
- Cardiolipin Binding: SS-31 enters cells directly and binds to cardiolipin, a lipid found on the inner mitochondrial membrane.
- Energy Production: By binding to cardiolipin, it organizes the electron transport chain to run efficiently, maximizing ATP (energy) production.
- Antioxidant Effect: It protects mitochondria by scavenging reactive oxygen species (ROS) and preventing structural swelling.
National Institutes of Health (.gov) +4
Potential Benefits & Research
- Cellular Repair: Explored for mitigating the fundamental oxidative stress associated with aging.
- Organ Protection: Studied in clinical and laboratory models for its potential to protect against conditions involving mitochondrial dysfunction, such as heart failure, kidney disease, and neurodegenerative decline.
- Mitochondrial Diseases: Developed for genetic mitochondrial diseases, like primary mitochondrial myopathy.
For Research Use Only
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